Knockout of p21-activated kinase-1 attenuates exercise-induced cardiac remodelling through altered calcineurin signalling

Conclusions
Our data suggest that Pak1 is essential for adaptive physiological cardiac remodelling and support previous evidence that demonstrates Pak1 signalling is important for cardiac growth and survival.

Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Davis, R. T., Simon, J. N., Utter, M., Mungai, P., Alvarez, M. G., Chowdhury, S. A. K., Heydemann, A., Ke, Y., Wolska, B. M., Solaro, R. J. Tags: Cardiac biology and remodelling Source Type: research