Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood-Brain Barrier Integrity and CNS Homeostasis.

CONCLUSIONS: -These results demonstrate the prerequisite role of endothelial β-catenin in maintaining the integrity of adult BBB. The results suggest that BBB dysfunction secondary to defective β-catenin transcription activity is a key pathogenic factor in hemorrhagic stroke, seizure activity and CNS inflammation. PMID: 26538583 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26538583?dopt=Abstract

Source: Circulation - November 4, 2015 Category: Cardiology Authors: Tran KA, Zhang X, Predescu D, Huang X, Machado RF, Göthert JR, Malik AB, Valyi-Nagy T, Zhao YY Tags: Circulation Source Type: research