Hormonal Contraceptives And Venous Thromboembolism: Are Inflammatory Bowel Disease Patients At Increased Risk? A retrospective study on a prospective database

Publication date: Available online 3 November 2015 Source:Annals of Medicine and Surgery Author(s): Gianluca Pellino, Guido Sciaudone, Francesca Caprio, Giuseppe Candilio, G Serena De Fatico, Alfonso Reginelli, Silvestro Canonico, Francesco Selvaggi Recent studies showed an increased the risk of venous thromboembolism (VTE) in patients receiving oral hormonal contraceptives. Inflammatory bowel disease (IBD) often affect young patients and represents a pro-coagulant condition. This could result from active inflammation, but a potential role for genetic and molecular factors has been suggested. Hormonal contraceptives have also been associated with increased risk of VTE and the risk may be greater in IBD patients that already are in a pro-coagulant status, but no definitive data are available in this population. The purpose of our study was to seek for differences of the risk of VTE in IBD patients receiving hormonal contraceptives compared with controls. This is a retrospective study. We interrogated a prospectively maintained database of IBD patients observed at our outpatient clinic between 2000 and 2014. All female patients managed conservatively, with no active disease, who were taking oral hormone contraceptives in the study period, were included. Patients observed for other-than-IBD conditions at our Unit and at the Unit of Gynaecology and Obstetrics, receiving contraceptives, served as controls (ratio 1:2). Patients with cancer, those receiving hormo...
Source: Annals of Medicine and Surgery - Category: Journals (General) Source Type: research