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Drug for digestive problem can extend survival for many advanced cancer patients

Advanced cancer patients given a drug designed to relieve constipation caused by pain killers lived longer with less tumor progression than those who did not receive or respond to the drug, researchers report. This is the first study in humans to associate opioid blockade with longer survival. It suggests that methylnaltrexone, approved in 2008 for prevention of opioid-induced constipation, should play a larger role in cancer therapy.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CERVICAL cancer symptoms include unusual bleeding, back pain, and passing more stools than usual. But, you should never ignore constipation pain, as it could be a sign of a tumour.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: AGA Abstracts Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: AGA Abstracts Source Type: research
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: AGA Abstracts Source Type: research
Aims The aim of this study was to evaluate long-term quality of life and urinary and sexual function in long-term cervical cancer survivors previously treated with radical hysterectomy (RH) type C2/type III. Methods All patients who presented at Campus Bio-Medico of Rome for RH type C2/type III for cervical cancer were considered eligible for this retrospective study protocol. We included exclusively patients with complete response to primary treatment with at least 36 months of follow up. Included subjects were interviewed with the European Organization for Research and Treatment of Cancer QLQ-CX24 Questionnaire, Eur...
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Quality of Life Source Type: research
Conclusions: While the types and direct effects of the cancers, the young age distribution, and the true symptomatic status of this Bangladeshi population studied may explain the described characteristics, the observations deserve exploration of other causes with specific therapeutic implications. These patients appear to have been partially treated for pain, and in particular, environmental factors such as extreme heat and its consequences appear more likely causes of moderate levels of multiple symptoms, which collectively magnified patients' suffering. Greater attention to gastrointestinal symptoms and sleep disturb...
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
Children and adults with malignancies often require opioids for pain, which commonly cause constipation. The resulting effect on quality of life can be significant.1 As no drugs have been approved for patients with malignancies and opioid-induced constipation, several drugs approved for opioid-induced constipation in non-cancer pain (including opioid antagonists such as prolonged-release naloxone combined with oxycodone, methylnaltrexone, naloxegol, naldemedine, or alvimopan) are chosen when laxatives fail.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Concise Advice for Clinicians Source Type: research
Conclusions: The findings from this study demonstrate that use of transdermal fentanyl for the management of moderate or severe cancer pain had more advantages compared to oral morphine.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Authors: Lei YY, Ho SC, Cheng A, Kwok C, Lee CI, Cheung KL, Lee R, Loong HHF, He YQ, Yeo W Abstract Background: The 2007 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guideline provides recommendations for cancer prevention among cancer survivors. Limited data have examined whether guideline adherence is related to health-related quality of life (HRQoL) among Chinese patients with breast cancer. Methods: An ongoing prospective cohort study involving 1,462 Chinese women with early-stage breast cancer assessed exercise, diet, and body mass index (BMI) at baseline and at 18-months follo...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Conclusions: Obtained results suggest that an IONB can also be suitable for elderly patients compared with an IC with few and selected advantages in favour of the former UD. Preoperative patient ’s selection, counselling, education and active participation in the decision-making process lead to a more suitable choice of treatment.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
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