Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-Term Self-Renewal of Murine Hematopoietic Stem Cells

Conclusions: Our findings indicate that AHR activation by TCDD in the fetus during pregnancy leads to impairment of long-term self-renewal of hematopoietic stem cells. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Laiosa MD, Tate ER, Ahrenhoerster LS, Chen Y, Wang D. Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-Term Self-Renewal of Murine Hematopoietic Stem Cells. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1509820 Received: 12 February 2015 Accepted: 15 October 2015 Advance Publication: 23 October 2015 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehp508@niehs.nih.gov. Our staff will work with you to assess and meet you...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research