Cost-Effectiveness of Conjugate Pneumococcal Vaccination In Croatia
The objective of this study is to estimate the potential effectiveness and cost-effectiveness of vaccinating infants with the pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) compared to the 13-valent pneumococcal conjugate vaccine (PCV-13) in Croatia. These vaccines are currently available only for risk groups and on private market with a limited uptake, representing less than 10% of annual birth cohort.
The evidence shows that people with inflammatory bowel disease are at increased risk of herpes zoster.1 The cohort study conducted by Khan et al2 published in Clinical Gastroenterology and Hepatology revealed that vaccination for herpes zoster was associated with a decreased risk of herpes zoster among older people with inflammatory bowel disease. Khan et al found that the incidence of herpes zoster was higher for unvaccinated than vac cinated people (6.97 versus 4.09 per 1000 patient-years).2 The absolute risk reduction was about 0.288%, resulting in the number needed to treat of 347.
Condition: Middle East Respiratory Syndrome Coronavirus Intervention: Biological: ChAdOx1 MERS Sponsors: King Abdullah International Medical Research Center; University of Oxford Not yet recruiting
This NIHR Signal says that the risk of shingles is about 10% per year in adults after autologous stem cell transplant. The evidence summary indicates that two doses of deactivated herpes zoster vaccine could be a safe and effective way to reduce that risk by about two thirds.This effect is similar to another, heat-treated, non-live vaccine. Either vaccine could reduce the pain and need for medical treatment associated with shingles, and long-lasting complications such as post-herpetic neuralgia. It's not yet known if people need to continue taking acyclovir as well.
This collection of resources has been relaunched for 2019. The campaignurges people to always take their doctor's, pharmacist's or nurse's advice on antibiotics. It provides effective self-care advice to help people and their families feel better if they are not prescribed antibiotics. Antibiotics are essential to treat serious bacterial infections such as pneumonia, meningitis and sepsis. They also help to ward off infections during chemotherapy, caesarean sections and other surgeries. However, while antibiotics are vital to treating life-threatening infections, they are frequently being used to treat less serious illness...
Officials have restarted the distribution of a Flu vaccine for one million children following “concerning delays”.
Authors: He P, Guo Y, Wang J, Yan L, Feng A Abstract Pneumonia is a major cause of morbidity and mortality of infectious diseases, especially in children. Ripasudil (K-115), a selective ROCK inhibitor, is a promising emerging drug against glaucoma, and reported to have anti-inflammatory activity. However, the anti-inflammatory effect of ripasudil still remains unclear in pneumonia. The goal of this study is to investigate the role and the underlying mechanism of ripasudil in pneumonia. BALB/c mice were used to establish an acute pneumonia model of mice by injection of lipopolysaccharide (LPS) intraperitoneally. Rip...
ConclusionsAny difference in price between PHiD-CV and PCV13 is expected to be the key driver of vaccine choice for preventing childhood pneumococcal disease in Turkey. At price parity, PHiD-CV use is likely to be a dominant strategy over the use of PCV13.
CONCLUSION: The results from this study suggest that our NTHi AOM coinfection model is useful for assessing protein vaccines. PMID: 30136923 [PubMed - as supplied by publisher]
CONCLUSION: Non-typeable H. influenzae (NTHi), mostly derived from pneumonia and AOM, were genetically diverse, in contrast to the predominance of H. influenzae type b (Hib) among meningitis cases. The associations between certain STs and β-lactam resistance among NTHi were confirmed. PMID: 29595417 [PubMed - as supplied by publisher]
Authors: K L Ç H, Akyol S, Parkan ÕM, Dinç G, Sav H, Aydemir G Abstract Haemophilus influenzae can cause invasive and severe infections in both adults and children such as otitis media, sinusitis, pneumonia, meningitis and bacteremia. The emerging antibiotic resistance in recent years against ampicillin and several other antibiotics among strains of H. influenzae gives cause for serious concern. Here, we investigate ß-lactamase (BL) activity in clinical isolates of H. influenzae, profile their resistance to antibiotics, and characterize the clonal relationship of the isolates. Antibiotic ...