Giant cell hepatitis with Coombs-positive hemolytic anemia: Possible association with Kabuki syndrome?

A 7-month-old infant presented with acute hemolytic anemia characterized by severe pallor, hepatosplenomegaly, hemoglobin 4.6g/dl, total bilirubin 4.02mg/dl (unconjugated 2.29), positive direct Coombs’ test. The child received erythrocytes transfusion and therapy with high-dose of steroids, first intravenously and then orally. Laboratory showed also: AST 1088 U/l, ALT 1176 U/l, GGT 155 U/l, conjugated bilirubin 1.83mg/dl, LDH 2429 U/l, INR 1. Serological tests for HAV, HBV, HCV, EBV, CMV, HSV, Parvovirus B19, HIV were negative.

Source: Digestive and Liver Disease - October 8, 2015 Category: Gastroenterology Authors: F. Chiatto, G. Ranucci, F. Di Dato, V. Gallo, M.G. Puoti, M.I. Spagnuolo, R. Iorio Tags: P049 Source Type: research