TWEAK/Fn14 interaction promotes oxidative stress through NADPH oxidase activation in macrophages

Conclusions Our results suggest that TWEAK regulates vascular damage by stimulating ROS production in an Nox2-dependent manner. These new insights into the TWEAK/Fn14 axis underline their potential use as therapeutic targets in atherosclerosis.

http://cardiovascres.oxfordjournals.org/cgi/content/short/108/1/139?rss=1

Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Madrigal-Matute, J., Fernandez-Laso, V., Sastre, C., Llamas-Granda, P., Egido, J., Martin-Ventura, J. L., Zalba, G., Blanco-Colio, L. M. Tags: Vascular biology Source Type: research