Proportion of undercarboxylated osteocalcin and serum P1NP predict incidence of myocardial infarction in older men.

CONCLUSIONS: Areduced proportion of undercarboxylated osteocalcin or higherP1NPare associated with increased incidence of MI. UcOC/TOC ratio and P1NP predict risk of MI but not stroke, in a manner distinct from CTX. Further studies are needed to investigate potential mechanisms by which bone turnover markers related to metabolic risk and to collagen formation could modulate cardiovascular risk.
PMID: 26308289 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - August 26, 2015 Category: Endocrinology Authors: Yeap BB, Alfonso H, Chubb SA, Byrnes E, Beilby JP, Ebeling PR, Allan CA, Schultz C, Hankey GJ, Golledge J, Flicker L, Norman PE Tags: J Clin Endocrinol Metab Source Type: research