MicroRNA-1298 is regulated by DNA methylation and affects vascular smooth muscle cell function by targeting connexin 43

Conclusion
Our data demonstrate a specific role of the upstream DNA methylation/miR-1298/Cx43 pathway in regulating VSMC function and suggest that modulation of miR-1298 levels may offer a novel therapeutic approach for ASO.

Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Hu, W., Wang, M., Yin, H., Yao, C., He, Q., Yin, L., Zhang, C., Li, W., Chang, G., Wang, S. Tags: Vascular biology Source Type: research