Dermcidin: a skeletal muscle myokine modulating cardiomyocyte survival and infarct size after coronary artery ligation

Conclusion
Our data demonstrate that chronic limb ischaemia activates detrimental pathways in the ischaemic heart through humoral mechanisms of remote organ crosstalk. Thus, DCD may represent a novel important myokine modulating cardiomyocyte survival and function.

Source: Cardiovascular Research - August 18, 2015 Category: Cardiology Authors: Esposito, G., Schiattarella, G. G., Perrino, C., Cattaneo, F., Pironti, G., Franzone, A., Gargiulo, G., Magliulo, F., Serino, F., Carotenuto, G., Sannino, A., Ilardi, F., Scudiero, F., Brevetti, L., Oliveti, M., Giugliano, G., Del Giudice, C., Ciccarelli, Tags: Cardiac biology and remodelling Source Type: research