Abstract 3558: uPAR mediated endothelial targeting by oncolytic measles virus

Conclusion: The above results demonstrate the improved ability of uPAR retargeted oncolytic measles virus to infect, replicate and successfully infect angiogenic endothelial cells, as well as successful EC to TC transfer in vitro, resulting in tumor cell cytotoxicity. Vascular targeting by oncolytic MVs may result in improved tumor cell delivery in vivo, and enhanced antitumor effects.Citation Format: Marcela M. Toro Bejarano, Yuqi Jing, Krisztina Kovacs, Jaime Merchan. uPAR mediated endothelial targeting by oncolytic measles virus. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3558. doi:10.1158/1538-7445.AM2015-3558

Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Toro Bejarano, M. M., Jing, Y., Kovacs, K., Merchan, J. Tags: Experimental and Molecular Therapeutics Source Type: research