In vitro activity of minocycline alone or in combinations in multidrug resistant Acinetobacter baumannii isolates.

In vitro activity of minocycline alone or in combinations in multidrug resistant Acinetobacter baumannii isolates. J Med Microbiol. 2015 Jul 31; Authors: Rodríguez CH, Nastro M, Vay C, Famiglietti A Abstract Minocycline (MIN) usually shows good activity against Acinetobacter baumannii strains. The reintroduction to the market of intravenous MIN provides an additional agent to the limited options for the treatment of A. baumannii infections. The activity of MIN as single agent and in combination with rifampicin, colistin or imipenem was evaluated by means of killing curves and twenty-four-hour-time kill curves in five A. baumannii isolates which were selected on the basis of different antimicrobials resistance profiles. MIN showed bacteriostatic activity in 3 isolates (2XMIC or 16XMIC) and bactericidal in the other two ones (64XMIC). In isolates harbouring the tet(B) gene, the associations studied were always indifferent. However, in isolates not harbouring tet(B), the use of MIN in combination showed a rapid synergistic effect (at 4hs) in four out of nine combinations (2 with rifampicin and 1 with imipenem and colistin, respectively). At 24 hs, this effect was observed in six out of nine combinations (2 in each association). Minocycline in combination with rifampicin, imipenem and colistin showed bactericidal synergy in most of the isolates which did not harbour the tet(B) gene but the combinations were not synergistic in tet(B) pos...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research