Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis: A Secondary Analysis of a Randomized Clinical Trial

CONCLUSIONS AND RELEVANCE: The findings of this post hoc analysis suggest that, among ELBW infants with the hemoglobin ranges occurring in the TOP trial, exposure to RBC transfusions was not temporally associated with a higher risk of NEC during 72-hour posttransfusion hazard periods. Given that the incidence rate of NEC peaked between postnatal days 20 and 29 among infants with lower hemoglobin values, a more in-depth examination of this at-risk period using larger data sets is warranted.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01702805.PMID:38700862 | DOI:10.1001/jamanetworkopen.2024.9643

Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Ariel A Salas Elizabeth Gunn Waldemar A Carlo Edward F Bell Abhik Das Cassandra D Josephson Ravi M Patel Sylvia Tan Haresh Kirpalani Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network Source Type: research