In vivo validation of late-onset Alzheimer's disease genetic risk factors
DISCUSSION: These results provide an initial functionalization of 11 candidate risk variants and identify potential preclinical models for testing targeted therapeutics.HIGHLIGHTS: A novel approach to validate genetic risk factors for late-onset AD (LOAD) is presented. LOAD risk variants were knocked in to conserved mouse loci. Variant effects were assayed by transcriptional analysis. Risk variants in Abca7, Mthfr, Plcg2, and Sorl1 loci modeled molecular signatures of clinical disease. This approach should generate more translationally relevant animal models.PMID:38687251 | DOI:10.1002/alz.13840
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Michael Sasner Christoph Preuss Ravi S Pandey Asli Uyar Dylan Garceau Kevin P Kotredes Harriet Williams Adrian L Oblak Peter Bor-Chian Lin Bridget Perkins Disha Soni Cindy Ingraham Audrey Lee-Gosselin Bruce T Lamb Gareth R Howell Gregory W Carter Source Type: research