Understanding autoimmune pancreatitis: Clinical features, management challenges, and association with malignancies

World J Gastroenterol. 2024 Apr 21;30(15):2091-2095. doi: 10.3748/wjg.v30.i15.2091.ABSTRACTIn this editorial we comment on the article by Jaber et al. Autoimmune pancreatitis (AIP) represents a distinct form of pancreatitis, categorized into AIP-1 and AIP-2, characterized by obstructive jaundice, lymphoplasmacytic infiltrate, and fibrosis. AIP-1, associated with elevated immunoglobulin G4 (IgG4) levels, exhibits higher relapse rates, affecting older males, while AIP-2 is less common and linked to inflammatory bowel disease. AIP is considered a manifestation of IgG4-related systemic disease, sharing characteristic histological findings. Steroids are the primary treatment, with emerging biomarkers like interferon alpha and interleukin-33. AIP poses an increased risk of various malignancies, and the association with pancreatic cancer is debated. Surgery is reserved for severe cases, necessitating careful evaluation due to diagnostic challenges. AIP patients may have concurrent PanINs but display favorable long-term outcomes compared to pancreatic cancer patients. Thorough diagnostic assessment, including biopsy and steroid response, is crucial for informed surgical decisions in AIP.PMID:38681985 | PMC:PMC11045485 | DOI:10.3748/wjg.v30.i15.2091
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Source Type: research