Neuroanatomical and Behavioral Profiles in 3q29 Deletion Syndrome: An Integrative Investigation of Gene-Brain-Behavior Relationships

Among high-impact genomic variants associated with severe neurodevelopmental disorders, the 3q29 deletion (3q29Del) stands out, conferring a 40-100-fold elevated risk of schizophrenia, alongside a heightened susceptibility to autism, intellectual disability and ADHD. Despite growing knowledge of its clinical associations, its neurobiological consequences are largely unknown.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Esra Sefik, Ryan M. Guest, Kuaikuai Duan, Katrina Aberizk, Roberto Espana, Katrina Goines, Derek M. Novacek, Melissa M. Murphy, Adam E. Goldman-Yassen, Joseph F. Cubells, Stormi P. White, Celine A. Saulnier, Cheryl Klaiman, Longchuan Li, Elaine F. Walker, Source Type: research