36. Unique Functional Neuroimaging Signatures of Genetic Versus Clinical High Risk for Psychosis

22q11.2 Deletion Syndrome (22qDel) is a copy number variant (CNV) associated with schizophrenia and other neurodevelopmental disorders. Studying this population provides a framework for linking genes to neuropsychiatric phenotypes. Adolescents at clinical high risk for psychosis (CHR) have sub-threshold psychosis symptoms without a known genetic risk factor. Here we compared these high-risk populations on measures of functional connectivity and mapped these results to biological pathways with multi-modal data.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Charles Schleifer, Sarah Chang, Carolyn Amir, Kathleen P. O'Hora, Hoki Fung, Leila Kushan-Wells, Eileen Daly, Fabio Di Fabio, Marianna Frascarelli, Maria Gudbrandsen, Wendy R. Kates, Declan Murphy, North American Longitudinal Prodromal Study-2 (NAPLS2) Co Source Type: research