419. Scaling of Smaller Pyramidal Neuron Size and Lower Energy Production in Schizophrenia

Dorsolateral prefrontal cortex (DLPFC) dysfunction in schizophrenia appears to reflect alterations in layer 3 pyramidal neurons (L3PNs) that include smaller cell bodies and lower expression of mitochondrial energy production genes. However, somal size studies have used biased strategies for identifying L3PNs, energy production markers have not been assessed in individual L3PNs, and the relationship between these measures has not been assessed in the same L3PNs.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research