Signature of altered retinal microstructures and electrophysiology in schizophrenia spectrum disorders is associated with disease severity and polygenic risk

Optical coherence tomography (OCT) and electroretinography (ERG) studies have revealed structural and functional retinal alterations in individuals with schizophrenia spectrum disorders (SSD). However, it remains unclear which specific retinal layers are affected, how the retina, brain, and clinical symptomatology are connected, and how alterations of the visual system are related to genetic disease risk.

Source: Biological Psychiatry - April 26, 2024 Category: Psychiatry Authors: Emanuel Boudriot, Vanessa Gabriel, David Popovic, Pauline Pingen, Vladislav Yakimov, Sergi Papiol, Lukas Roell, Genc Hasanaj, Simiao Xu, Joanna Moussiopoulou, Siegfried Priglinger, Christoph Kern, Eva C. Schulte, Alkomiet Hasan, Oliver Pogarell, Peter Fal Tags: Archival Report Source Type: research