Magnolol promotes the autophagy of esophageal carcinoma cells by upregulating < em > HACE1 < /em > gene expression

This study demonstrates that magnolol increases the protein levels of LC3 II, accompanied by increased HACE1 protein levels in both esophageal carcinoma cells and xenograft tumors. HACE1-knockout (KO) cell lines are generated, and the ablation of HACE1 eliminates the anti-proliferative and autophagy-inducing effects of magnolol on esophageal carcinoma cells. Additionally, our results show that magnolol primarily promotes HACE1 expression at the transcriptional level. Therefore, this study shows that magnolol primarily exerts its antitumor effect by activating HACE1-OPTN axis-mediated autophagy. It can be considered a promising therapeutic drug for esophageal carcinoma.PMID:38660717 | DOI:10.3724/abbs.2024044
Source: Acta Biochimica et Biophysica Sinica - Category: Biochemistry Authors: Source Type: research