USP19 regulates DNA methylation damage repair and confers temozolomide resistance through MGMT stabilization

CONCLUSION: The regulation of MGMT ubiquitination by USP19 plays a critical role in DNA methylation damage repair and GBM patients' temozolomide chemotherapy response.PMID:38644551 | PMC:PMC11033335 | DOI:10.1111/cns.14711

Source: CNS Neuroscience and Therapeutics - April 22, 2024 Category: Neuroscience Authors: Jiaqi Liu Kaikai Wang Qian Zhu Yixin Zhang Yuping Chen Zhenkun Lou Jian Yuan Source Type: research