5HT2A modulation attenuates pancreatic cancer induced pain mouse model by inhibiting HDAC

CONCLUSIONS: Data revealed that 5HT2A antagonist ameliorates pain associated with pancreatic cancer mice by HDAC inhibition and inflammatory cytokines. The result of investigation supports that modulation of 5HT2A receptor could be used clinically to protects neuropathic pain in pancreatic cancer.PMID:38629654 | PMC:PMC11020633 | DOI:10.1590/acb392324

Source: Acta Cirurgica Brasileira - April 17, 2024 Category: Surgery Authors: Weiwei Fan Xijia Yang Liang Zhou Jianqing Xu Weihua Huang Alok Shiomurti Tripathi Source Type: research