Replicating Human Characteristics: A Promising Animal Model of Central Fatigue

In conclusion, our ADF+MMPM model comprehensively replicated the features of human central fatigue and is a promising platform for preclinical research. Furthermore, the pivotal role of mitochondrial energy metabolism and oxidative stress damage in the occurrence of central fatigue in the hippocampus and skeletal muscle tissues was corroborated.PMID:38642899 | DOI:10.1016/j.brainresbull.2024.110951

Source: Brain Research - April 20, 2024 Category: Neurology Authors: Yifei Zhang Zehan Zhang Qingqian Yu Bijuan Lan Qinghuan Shi Ruting Li Ziheng Jiao Weiyue Zhang Feng Li Source Type: research