Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans

CONCLUSIONS: Plaque EAA is a strong and independent marker of poor outcome in patients with severe atherosclerosis. Plaque EAA was linked to mesenchymal endothelial and smooth muscle cells. Endothelial-to-mesenchymal transition was associated with EAA, which was experimentally validated. Epigenetic aging mechanisms may provide new targets for treatments that reduce atherosclerosis complications.PMID:38634280 | DOI:10.1161/ATVBAHA.123.320692

Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 18, 2024 Category: Cardiology Authors: Ernest Diez Benavente Robin J G Hartman Tim R Sakkers Marian Wesseling Yannicke Sloots Lotte Slenders Arjan Boltjes Barend M Mol Gert J de Borst Dominique P V de Kleijn Koen H M Prange Menno P J de Winther Johan Kuiper Mete Civelek Sander W van der Laan S Source Type: research