5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells

This study suggests that 5-AZA, by upregulating the expression level of SOCS3 and PTPN6/SHP1, reduced STAT3 activation and improved the outcome of treatment targeting this transcription factor in PEL cells.PMID:38534772 | PMC:PMC10968859 | DOI:10.3390/cimb46030156

Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Michele Di Crosta Andrea Arena Rossella Benedetti Maria Saveria Gilardini Montani Mara Cirone Source Type: research