Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation

CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699

Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research