Predictive factors for radiation-induced pituitary damage in pediatric patients with brain tumors

Multiple studies have demonstrated hypothalamic –pituitary dysfunction in survivors of childhood and adolescent brain tumors. Hypothalamic-pituitary dysfunction may reflect direct injury by the tumor itself or by surgery, as well as treatment-induced damage, mainly due to cranial irradiation. Other risk factors for pituitary hormone deficiencie s include concurrent chemotherapy and young age at the time of irradiation [1–7]. Hypothalamic-pituitary dysfunction secondary to radiation is time-dependent, with both increased incidence and severity of hormonal deficits with longer follow-up [8].

Source: Radiotherapy and Oncology - April 17, 2024 Category: Radiology Authors: Larisa Gorenstein, Shai Shrot, Michal Ben-Ami, Eve Stern, Michal Yalon, Chen Hoffmann, Shani Caspi, Michal Lurye, Amos Toren, Gadi Abebe-Campino, Dalit Modan-Moses Tags: Original Article Source Type: research