V-set and immunoglobulin domain containing 4 inhibits oxidative stress, mitochondrial dysfunction, and inflammation to attenuate Parkinson's disease progression by activating the JAK2/STAT3 pathway

V-set and immunoglobulin domain containing 4 (VSIG4) inhibits neurological dysfunction, microglial M1 polarization, and inflammation to participate in the progression of neurological disorders, but evidence regarding Parkinson's disease (PD) is scarce. The present study intended to investigate the engagement of VSIG4 in PD progression, and the potential mechanism.

Source: Journal of Neuroimmunology - April 17, 2024 Category: Allergy & Immunology Authors: Pingping Cai, Junmei Wang, Jiangtao Xu, Min Zhang, Xinxin Yin, Shengquan He, Jingcong Zhuang Source Type: research