Corticospinal tract hyperintensity in patients with LGI1-antibody encephalitis and other central nervous system disorders with neuroglial antibodies
The frequency of corticospinal tract (CST) T2/FLAIR hyperintensity in disorders with neuroglial antibodies is unclear. Herein, we retrospectively reviewed brain MRIs of 101 LGI1-antibody encephalitis patients, and observed CST hyperintensity in 30/101(30%). It was mostly bilateral (93%), not associated with upper motor neuron signs/symptoms (7%), and frequently decreased over time (39%). In a systematic review including patients with other neuroglial antibodies, CST hyperintensity was reported in 110 with neuromyelitis optica (94%), myelin oligodendrocyte glycoprotein-associated disease (2%), Ma2-antibody (3%) and GAD65-antibody paraneoplastic neurological syndrome (1%).
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Lucia Campetella, Macarena Villagran Garc ía, Antonio Farina, Marie Benaiteau, Raffaele Iorio, Paolo Calabresi, Alberto Vogrig, Salvatore Versace, Nicolás Lundahl Ciano-Petersen, Elodie Bicilli Brotelle, Pierre Branger, Clotilde Verlut, Sophie Langner-L Tags: Short Communication Source Type: research
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