Viruses, Vol. 16, Pages 620: Antibodies Induced by Smallpox Vaccination after at Least 45 Years Cross-React with and In Vitro Neutralize Mpox Virus: A Role for Polyclonal B Cell Activation?

Conclusions: ELISA and WB performed using supernatant of VV- or MPXV-infected cells are suitable to identify individuals vaccinated against smallpox at more than 45 years from immunization and individuals convalescing from a recent MPXV infection. ELISA and WB results show a good correlation with PRNT. Data confirm that a smallpox vaccination induces a long-lasting memory in terms of specific IgG and that antibodies raised against VV may neutralize MPXV in vitro. Finally, higher titers of VV-specific antibodies and higher frequency of VV-specific memory T cells in LTBI individuals suggest a role of polyclonal non-specific activation in the maintenance of immunologic memory.

Source: Viruses - April 17, 2024 Category: Virology Authors: Sabrina Mariotti Giulietta Venturi Maria Vincenza Chiantore Raffaela Teloni Riccardo De Santis Antonello Amendola Claudia Fortuna Giulia Marsili Giorgia Grilli Maria Stella Lia Seble Tekle Kiros Filippo Lagi Alessandro Bartoloni Angelo Iacobino Raffaele C Tags: Article Source Type: research