Risks and benefits of hormone therapy after menopause for cognitive decline and dementia: A conceptual review

The evidence and our beliefs about the beneficial or harmful effects of hormone therapy (HT) on brain aging have changed quite dramatically over time. In the last five years, several observational studies have shown an increased risk of dementia in women who had received HT [1 –5]. However, these results are opposite to the results of several observational studies and some clinical trials published over the last 30 years [6,7]. Therefore, in a 2022 editorial, we suggested that the answer to the simple question: “Is HT protective or harmful for cognitive decline and dementia?” is actually quite complex and may vary across subgroups of women [7].
Source: Maturitas - Category: Primary Care Authors: Tags: Review article Source Type: research