CircHIPK3 targets DRP1 to mediate hydrogen peroxide-induced necroptosis of vascular smooth muscle cells and atherosclerotic vulnerable plaque formation

CONCLUSION: CircHIPK3 interact with DRP1 involve in H2O2 induced Mitochondrial damage and necroptosis of VSMCs, and Silencing circHIPK3 in vivo can reduce atherosclerotic vulnerable plaque formation. Our research findings may have applications in providing diagnostic biomarkers for vulnerable plaques.PMID:38621622 | DOI:10.1016/j.jare.2024.04.011

https://pubmed.ncbi.nlm.nih.gov/38621622/?utm_source=no_user_agent&utm_medium=rs...

Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Xiaolu Li Yanyan Yang Zhibin Wang Xiaotong Lin Xiuxiu Fu Xiangqin He Meixin Liu Jian-Xun Wang Tao Yu Pin Sun Source Type: research