Cancers, Vol. 16, Pages 1514: Assessment of PSMA Expression of Healthy Organs in Different Stages of Prostate Cancer Using [68Ga]Ga-PSMA-11-PET Examinations

Cancers, Vol. 16, Pages 1514: Assessment of PSMA Expression of Healthy Organs in Different Stages of Prostate Cancer Using [68Ga]Ga-PSMA-11-PET Examinations Cancers doi: 10.3390/cancers16081514 Authors: Holger Einspieler Kilian Kluge David Haberl Katrin Schatz Lukas Nics Stefan Schmitl Barbara Katharina Geist Clemens P. Spielvogel Bernhard Grubmüller Pascal A. T. Baltzer Gero Kramer Shahrokh F. Shariat Marcus Hacker Sazan Rasul The efficacy of radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) is currently being investigated for its application in patients with early-stage prostate cancer (PCa). However, little is known about PSMA expression in healthy organs in this cohort. Collectively, 202 [68Ga]Ga-PSMA-11 positron emission tomography (PET) scans from 152 patients were studied. Of these, 102 PET scans were from patients with primary PCa and hormone-sensitive biochemically recurrent PCa and 50 PET scans were from patients with metastatic castration-resistant PCa (mCRPC) before and after three cycles of [177Lu]Lu-PSMA-RLT. PSMA-standardized uptake values (SUV) were measured in multiple organs and PSMA-total tumor volume (PSMA-TTV) was determined in all cohorts. The measured PET parameters of the different cohorts were normalized to the bloodpool and compared using t- or Mann–Whitney U tests. Patients with early-stage PCa had lower PSMA-TTVs (10.39 mL vs. 462.42 mL, p < 0.001) and showed di...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research