Viruses, Vol. 16, Pages 613: Risk of Cardiovascular Events in People with HIV (PWH) Treated with Integrase Strand-Transfer Inhibitors: The Debate Is Not Over; Results of the SCOLTA Study

Viruses, Vol. 16, Pages 613: Risk of Cardiovascular Events in People with HIV (PWH) Treated with Integrase Strand-Transfer Inhibitors: The Debate Is Not Over; Results of the SCOLTA Study Viruses doi: 10.3390/v16040613 Authors: Nicolò Corti Barbara Menzaghi Giancarlo Orofino Marta Guastavigna Filippo Lagi Antonio Di Biagio Lucia Taramasso Giuseppe Vittorio De Socio Chiara Molteni Giordano Madeddu Elena Salomoni Giovanni Francesco Pellicanò Emanuele Pontali Rita Bellagamba Benedetto Maurizio Celesia Antonio Cascio Eleonora Sarchi Roberto Gulminetti Leonardo Calza Paolo Maggi Giovanni Cenderello Alessandra Bandera Maria Aurora Carleo Katia Falasca Sergio Ferrara Salvatore Martini Giuliana Guadagnino Goffredo Angioni Olivia Bargiacchi Elena Delfina Ricci Nicola Squillace Paolo Bonfanti Cardiovascular disease (CVD) is common in people with HIV (PWH), and has great impact in terms of morbidity and mortality. Several intertwined mechanisms are believed to play a role in determining the increased risk of CVD, including the effect of certain antiretrovirals; among these, the role of integrase strand-transfer inhibitors (INSTIs) is yet to be fully elucidated. We conducted a multicenter, observational study comprising 4984 PWH evaluating the antiretroviral therapy (ART)-related nature of CVD in real life settings, both in naïve vs. treatment-experienced people. A comparison was conducted between INSTIs ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research