Filamin A heart valve disease as a genetic cause of inherited bicuspid and tricuspid aortic valve disease

Conclusion
The patients with FLNA variants present frequent aortic valve disease and worse outcomes. Bicuspid aortic valve is more frequent in patients carrying the FLNA-MVD variants. These unique features should be factored into the management of patients with dystrophic and/or bicuspid aortic valve.

Source: Heart - April 15, 2024 Category: Cardiology Authors: Delwarde, C., Toquet, C., Boureau, A. S., Le Ruz, R., Le Scouarnec, S., Merot, J., Kyndt, F., Bernstein, D., Bernstein, J. A., Aalberts, J. J. J., Le Marec, H., Schott, J.-J., Roussel, J.-C., Le Tourneau, T., Capoulade, R. Tags: Valvular heart disease Source Type: research