Clinical significance of < em > CDT1 < /em > mRNA expression in chronic hepatitis C or liver cirrhosis

We examined the association between the CDT1 mRNA expression and clinical conditions and long-term outcome. We then examined the association between serum cytokine/chemokine levels and CDT1 mRNA expression in 58 cases. The cumulative incidence rates of HCC development in cases with CDT1 mRNA in the low expression group showed significantly lower than those in the high expression group (p = 0.0391). A significant correlation was found between CDT1 mRNA expression and the extent of proliferation of atypical hepatocytes in hematoxylin and eosin-stained sections (p<0.0001). CDT1 mRNA expression has been associated with cytokines involved in tumorigenesis in experimental and human cancers. We found that cases with high CDT1 mRNA expression were at risk for developing HCC, even if they were CHC or LC.PMID:38510682 | PMC:PMC10948353 | DOI:10.3164/jcbn.23-54
Source: Journal of Clinical Biochemistry and Nutrition - Category: Nutrition Authors: Source Type: research