Biomarkers related to hypertrophy of the ligamentum flavum: a systematic review of the literature

CONCLUSIONS: Biomarkers such as TGF-β, IL-6, and collagen I and III have been consistently correlated with the development of HLF. However, the pathogenesis of HLF remains unclear due to the heterogeneity of the studies, patient populations, and research at the molecular level. Further studies are necessary to better characterize the pathogenesis of HLF and provide a more comprehensive understanding of how these biomarkers may aid in the diagnosis and treatment of HLF.PMID:38608299 | DOI:10.3171/2024.2.SPINE23991
Source: Journal of Neurosurgery.Spine - Category: Neurosurgery Authors: Source Type: research