Machine learning-based integration develops a stress response stated T cell (Tstr)-related score for predicting outcomes in clear cell renal cell carcinoma

CONCLUSIONS: This study provides a Tstr cell-related score for predicting outcomes and PD-1 blockade therapy response in ccRCC. Tstr cells may exert their pro-tumoral role in ccRCC, acting against mast cells, in the acute inflammatory tumor microenvironment. TNFSF13B could serve as a key biomarker related to TCs.PMID:38599101 | DOI:10.1016/j.intimp.2024.112017

Source: International Immunopharmacology - April 10, 2024 Category: Allergy & Immunology Authors: Shuai Yang Zhaodong Han Zeheng Tan Zhenjie Wu Jianheng Ye Shanghua Cai Yuanfa Feng Huichan He Biyan Wen Xuejin Zhu Yongkang Ye Huiting Huang Sheng Wang Weide Zhong Yulin Deng Source Type: research