Fibroblast-derived PI16 Drives the Physiological Process of Immune Cell Recruitment and Activation During Inflammatory Response

Chronic inflammatory pain affects over one-quarter of United States citizens (Dydyk, 2023). The extent and impact of chronic inflammatory pain is determined by myeloid cell-driven induction and resolution of inflammation. In previous studies, we have shown that PI16 (peptidase inhibitor 16), a fibroblast-derived protein of unknown function, controls neuropathic pain by facilitating crosstalk between fibroblasts at the endothelial barrier (Sighmar, 2020). We also showed that PI16 sustains Complete Freund ’s Adjuvant (CFA)-induced inflammatory pain (Garrity, 2023).
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research