Inflammatory Response in Peripheral and Central Nervous System Is Involved in Alzheimer ’s Disease Associated Pain

Neuropathic pain often occurs in older people, particularly in the patients with neurodegenerative diseases such as Alzheimer ’s disease (AD) related dementia (ADRD). The abnormality of pain response may be an early indicator of memory loss and cognitive impairment. Increasing evidence suggests that the chronic inflammation occurring in the brain of AD patients seems to be triggered by increased amyloid beta (Aβ) accumu lation. However, whether this inflammation in the peripheral and central nervous system (CNS) exacerbates the neuropathic pain and the progression of ADRD remains unclarified.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research