Surgical Rodent Model of Osteoarthritis Alters Joint Structure, Tactile Sensitivity, and the Brain

Osteoarthritis (OA) is a debilitating and painful joint disorder with a significant impact on patient ’s lives. However, the effects of OA on pain-processing regions in the brain are poorly understood. To address this gap, the current study investigates joint remodeling, pain-related behavior, and brain remodeling in a surgical rodent model of post-traumatic osteoarthritis. Male and female Fischer -344 rats (18-19 months) received either a skin-incision (n=6 male, n=10 female) or medial meniscus transection plus medial collateral ligament transection (MMT+MCLT) (n=5 male, n=11 female) surgery.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research