Differential bioenergetics in adult rodent cardiomyocytes isolated from the right versus left ventricle

The heart is a highly metabolically active organ with ∼90% of its ATP production derived from mitochondrial oxidative phosphorylation. Mitochondrial dysfunction associated with the bioenergetic collapse seen in left ventricular (LV) heart failure is characterized by depressed oxidative phosphorylation, a switch away from fatty acid oxidation, and alt ered mitochondrial dynamics. Accumulating evidence suggests that mitochondrial mechanisms underlying right ventricular (RV) failure may diverge from those of LV failure [1], underscoring the need for comparative study of RV versus LV.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research