Living Donor Lung Transplantation After Hematopoietic Stem Cell Transplantation From the Same Donor: A Risk Worth Taking

We report a successful case of father-to-child single-lobe LT, because of the complications of hematopoietic stem cell transplantation from the same donor, with initial low-dose immunosuppressive therapy and subsequent early discontinuation. Full donor chimerism was hypothesized to be a mechanism of transplant tolerance, and this postulated immunological benefit was deemed to outweigh the risks of living donation and the possible drawbacks of single compared with bilateral LT. Favorable size matching and donor's anatomy, accurate surgical planning, and specific expertise in pediatric transplantation also contributed to the optimal recipient and donor outcomes. Ten months after LD LT, the patient's steadily good lung function after withdrawal of immunosuppressive therapy seems to confirm the original hypothesis.PMID:38599763 | DOI:10.1016/j.chest.2023.12.022

Source: Chest - April 10, 2024 Category: Respiratory Medicine Authors: Stefania Camagni Lorenzo D'Antiga Fabiano Di Marco Lorenzo Grazioli Ezio Bonanomi Domenico Pinelli Marta Beretta Veronica Tintori Alessandro Lucianetti Michele Colledan Source Type: research