Waterhouse-Friderichsen syndrome, septic adrenal apoplexy

Vitam Horm. 2024;124:449-461. doi: 10.1016/bs.vh.2023.06.001. Epub 2023 Nov 8.ABSTRACTWaterhouse-Friderichsen syndrome is a rare but potentially fatal disorder of the adrenal gland characterized by bilateral adrenal hemorrhage. It is classically a result of meningococcal sepsis and presents acutely with features of shock, petechial rashes, abdominal pain, and non-specific symptoms such as headache, fatigue, and vomiting. Treatment consists of fluid resuscitation, corticosteroid replacement, and possibly surgery. The prognosis is poor despite treatment. This chapter will review the etiology, pathogenesis, clinical features, and management of the disease.PMID:38408808 | DOI:10.1016/bs.vh.2023.06.001
Source: Vitamins and Hormones - Category: Endocrinology Authors: Source Type: research