Decoding T Cell Clonal Dynamics in Acute Lung Rejection
Purpose: T cell-mediated acute cellular rejection (ACR) is a common complication in lung transplant (LTx) recipients within the first post-transplant year, affecting 30-50% of patients and is often associated with later development of chronic lung allograft dysfunction (CLAD). Traditional genomics studies, utilizing bulk RNA-Seq, lack the cellular granularity required to completely understand ACR. Our research leverages single-cell RNA +TCR sequencing (scRNAseq/TCRseq) to investigate the clonal repertoire and gene expression changes in expanded T cells during ACR, highlighting the crucial role of single-cell TCR sequencing in elucidating clonal dynamics and T-cell gene expression, and paving the way for potential therapeutic interventions.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: A. Potter, K. Wikenheiser-Brokamp, D. Hildeman, N. Sharma, M. Gu, K. Patel, M. Qureshi, M.M. Khan, C. Wallace, A. Ziady, Source Type: research
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