Longitudinal Increases in Bronchoalveolar Lavage Interleukin-6, Interleukin-8, Macrophage Inflammatory Protein-1a, and Transforming Growth Factor ß Predict Progressive Chronic Lung Allograft Dysfunction

Purpose: Participants in the ASSIST CLAD study of mesenchymal stromal cell therapy in new-onset chronic lung allograft dysfunction (CLAD) participated in an optional bronchoalveolar lavage (BAL) sub-study, providing an opportunity to investigate relationships between longitudinal change in BAL biomarkers and subsequent CLAD outcome.

Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: B. O'Sullivan, M. Tan, S.H. Apte, T. de Silva, P. Groves, V.P. Lutzky, G. Westall, D. Darley, M. Musk, A. Glanville, M. Malouf, C. Holmes-Liew, M. Sturm, S. Lawrence, D. Bushell, L. Holsworth, N. Lawson, L. Singleton, S. Timmins, D. Enever, H. Wildermuth, Source Type: research