Dynamic Contrast-Enhanced MRI in Lung Transplantation Recipients with and without CLAD

Purpose: Chronic lung allograft dysfunction (CLAD) accounts for 20-30% of post-transplantation deaths beyond the first year. The development of non-invasive diagnostic tests for CLAD is an unmet need. Our group has utilized dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with idiopathic pulmonary fibrosis and other lung diseases, to detect changes reflective of the microvasculature and the extravascular extracellular space. The purpose of this longitudinal observation study is to use DCE-MRI to detect functional changes in CLAD not otherwise obtainable.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research