Ex-Vivo Model of EMT: Efficacy of MVs from Bone Marrow Mesenchymal Stromal Cells

Purpose: Chronic Lung Allograft Dysfunction, is represented by progressive airway/interstitial fibrosis thought to be initiated by a process of epithelial-endothelial mesenchymal transition (EMT) which brings to myofibroblast differentiation and proliferation and extracellular matrix deposition. Recent reports have shown that microvescicles (MVs) derived from mesenchymal stem cells (MSCs) can reverse lung inflammation and resulting fibrosis. Among MVs, those obtained from bone marrow mesenchymal stromal cells (BMVs) seem to be active and enriched for anti-inflammatory factors.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research