Endothelin-1 Levels in Exercise-Induced Pulmonary Hypertension

Purpose: Endothelin-1 (ET-1), a potent vasoconstrictor, is elevated in heart failure as well as in pulmonary arterial hypertension (PAH). We sought to assess ET-1 levels in exercise induced pulmonary hypertension (EI-PH). EI=PH is a cause of decreased exercise capacity and is associated with a decreased life expectancy. EI-PH may precede the development of resting PH in a proportion of patients at risk, such as in thosewith PAH, and heart failure with preserved ejection fraction (HFpEF). EI-PH is thought to represent an intermediate stage between normal pulmonary pressure and overt PH.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research